Ibrutinib + R-CHOP in DLBCL: does age make a difference

Journal of Hematological Oncology
Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma.

The study did not meet its primary end point in the ITT or ABC population. However, in patients age younger than 60 years, ibrutinib plus R-CHOP improved EFS, PFS, and OS with manageable safety. In patients age 60 years or older, ibrutinib plus R-CHOP was associated with increased toxicity, leading to compromised R-CHOP administration and worse outcomes.

CBC (complete blood count)

Red blood cell countMale: 4.35-5.65 trillion cells/L*
(4.32-5.72 million cells/mcL**)Female: 3.92-5.13 trillion cells/L
(3.90-5.03 million cells/mcL)
HemoglobinMale: 13.2-16.6 grams/dL***
(132-166 grams/L)
Female: 11.6-15 grams/dL
(116-150 grams/L)
HematocritMale: 38.3-48.6 percent
Female: 35.5-44.9 percent
White blood cell count3.4-9.6 billion cells/L
(3,400 to 9,600 cells/mcL)
Platelet countMale: 135-317 billion/L
(135,000 to 317,000/mcL)
Female: 157-371 billion/L
(157,000-371,000/mcL)

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